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OBJECTIVE:To find suitable pharmaceutical care for our hospital. METHODS:The literature research and expert-consultation were adopted to determine the project of pharmaceutical care. Meanwhile,related information were analyzed by the questionnaire survey,statistical analysis interview and other methods in our hospital,such as the content,methods,level and quali-ty of pharmaceutical care. RESULTS:The determined project of the pharmaceutical care and five-point scale were as follows:pre-scription audit 4.53,medication consultation 4.21,prescription analysis 3.56,information about the medication for doctors and nurses 3.73,to establish medical records of hospitalized patients 3.14,ADR monitoring 4.33,drug therapy monitoring 4.31,to par-ticipate in clinical drug therapy 4.03,education about drug use 4.12,to design individualized dosing regimens 3.98,pharmaceutical research 3.58,to popularize pharmaceutical knowledge and education service 4.01. CONCLUSIONS:The hospital should empha-size clincal pharmacist work and software and hardware construction entirely;make the best of modern approach to carry out phar-maceutical care,mainly involving prescription audit and ADR monitoring. However,the problems are that the content of some pharmaceutical cares are not complete,and become a mere formality;clinical pharmacists do not receive systematic trained,the pharmaceutical researches have not been carried out systematically.
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OBJECTIVE:To establish the quality criteria for Gengnianjingxin capsules.METHODS:The constituents of Fructus Ligustri Lucidi,Radix Polygoni Multiflori,Semen Sesami Nigrum,and Flos Albiziae etc in Gengnianjingxin capsules were identified by TLC; the content of Paeoniflorin in Gengnianjingxin capsules was determined by HPLC. The chromatographic separation was performed on a ODS-(3)C18 column with mobile phase consisted of acetonitrile-phosphate 0.1% (16∶84) at a flow rate of 1.0mL?min-1. The detection wavelength was 230nm. RESULTS:Fructus Ligustri Lucidi,Radix Polygoni Multiflori,Semen Sesami Nigrum,and Flos Albiziae were all well-separated and clear spots were noted in TLC. The calibration curve was linear for Peoniflorin in the range of 0.256 2～1.281 0?g?mL-1(r=0.999 9), with the average recovery rate of 101.86% and RSD of 1.72%(n=5),CONCLUSION:The established criteria are suitable for the quality control of Gengnianjingxin capsules.
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OBJECTIVE:To establish phenol-vitriolic colorimetry for the assaying of polysaccharides in Torreya yunnanensis.METHODS:Detection wavelength was 490nm,slit-width was 2nm and record paper range was 20nm/cm;Torreya yun_nanensis from different origins were analyzed by HPCE.RESULTS:The linear range of anhydrous dextrose was 0.0 114mg～0.1 482mg(r=0.9 994);The average recovery rate was 98.3%(RSD=2.31%,n=5).The HPCE fingerprints of Torreya yu_nnanensis from different origins were basically the same,and 2 kinds of polysaccharides were contained in whcih.CONCLUSI_ON:The contents and compositions of polysaccharides of Torreya yunnanensis from different origins were of no significant diff_erence.
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BJECTIVE To identify the fruits of Lycium barbarum L.(LB) and Lycium chinense Mill.(LC).METHODS The proteins and polypeptides from the fruits of LB and LC were analysed by high-performance capillary electrophoresis.RESULTS LB could be distinguished from LC by their electrophorograms.CONCLUSION HPCE could be used for the pharmacognostic identification of Fructus Lycii.
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OBJECTIVE:To extract and analyze the compositions of fatty oil of Semen Pharbtidis METHODS:The fatty oil was extracted with CO2 supercritical fluid The content and compositions were determined by gravimetric analysis and GC-MS respectively RESULTS:The oil content of Semen Pharbtidis was 34 78% Among the fatty acids,linoleic acid,oleic acid and palmitic acid were dominant The unsaturated fatty acids accounted for 88 70% of the total fatty acids,and the major saturated fatty acid was palmitic acid CONCLUSION:The oil of Semen Pharbtidis is of high-quality,and the analysis results provide a scientific basis for exploitation and utilization of the oil of Semen Pharbtidis
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A TLC condition has been developed to purify the extraction from the leaf of Torreya Arn. plant,then an optimized HPLC method was used to determine the amount of taxol.HPLC chromatographic conditions were:colum:Shim Pack CLC ODS(150 mm?6.0 mm,5 ?m);mobile phase:methanol water(66∶34);flow rate: 0.5 ml/min;wavelength of the detector: 227 nm;colum temperature: 35℃.Using this method,we have determined the trace level of taxol in the leaf of Torreya Arn .plant successfully.There exists better linear relationship between peak height( Y ) and the concentration of detected sample( X ) within 100 500 ?g/ml.The average recovery rate is 85.7%( n =12);RSD is 7.8%.